1118767-15-9 Fmoc-L-Lys [OctotBu) -Glu- (otBu) -AEEA-AEEA] -OSu

Ubwa mbere, urunigi rw'uruhande rwa semaglutide rwakozwe kandi rukora, rukagira uruhare runini mubikorwa bya farumasi.Uru ruhererekane rw'uruhande, rufatanije na 26 ya lysine isigara ya peptide, ntabwo yongerera gusa imiterere ya semaglutide ahubwo inorohereza imikoranire yayo na molekile yihariye yibinyabuzima.

Icya kabiri, urunigi rw'uruhande rugizwe na karuboni 18 ya feri ya diacide, ikomatanyirizwa hamwe binyuze mu guhuza aside glutamic, molekile ebyiri za 8-amino-3,6-dioxaoctanoic aside (AEEA), na aside octadecanedioic.Uru ruhererekane rwuruhererekane rwihariye rwongera semaglutide ya alubumu, kugabanya impyiko no kongera ubuzima bwayo igice cyumubiri.Iki gikorwa kirekire cyongera imbaraga zo kuvura no kumara imiti.

Byongeye kandi, pegylation yuruhererekane rwuruhande rwongera imbaraga za semaglutide kandi ikagenda, bikagabanya kuyungurura impyiko no kwangirika kwa proteolyique.Iri hinduka kandi rigabanya pyrogenicite yibiyobyabwenge kandi ikarinda indwara ziterwa n’umubiri, kunoza itangwa ry’ibiyobyabwenge no kugumana aho bigenewe.