130622-05-8 Tert-butoxycarbonyl-D-glutamic aside (methyl ester) -methyl ester

Fluoroquinolone ifite spiba nini ya antibacterial, ibikorwa bikomeye bya antibacterial, reaction nkeya, reaction nziza ya tissue, bioavailable yo mu kanwa, intera ndende yubuyobozi hamwe nubuyobozi bworoshye.Zikunze gukoreshwa mu kuvura indwara zandura nko kwandura imyanya y'ubuhumekero no kwanduza inkari.Imiterere yimiti igabanya ubukana bwa fluoroquinolone irangwa no kuba hari fluor kumwanya wa gatandatu wa nucleus yababyeyi.
Nyamara, mu myaka 10 ishize, kubera igitutu cyatoranijwe giterwa no gukoresha cyane ubu bwoko bwibiyobyabwenge, imiti irwanya ibiyobyabwenge iriyongera, cyane cyane mu myaka yashize, umusonga witwa Streptococcus pneumoniae urwanya kwinolone, urwanya penisiline, antibiyotike ya macrolide na antibiotike ya quinolone.Muri icyo gihe, byagaragaye ko fluoroquinolone zimwe na zimwe zishobora gutera QTc intera ndende ya electrocardiogram, hepatotoxicity na Phototoxicity, ibyo bikaba byaragabanije kubishyira mu bikorwa.
Kugirango tuneshe amakosa yavuzwe haruguru ya fluoroquinolone, birihutirwa guteza imbere ibice bishya byubaka hamwe nibikorwa byiza bya antibacterial, antibacterial spécran nini kandi ntoya ishoboka ingaruka mbi ziterwa na bagiteri zirwanya imiti myinshi.Urukurikirane rw'imiti mishya ya fluoroquinolone idafite (NFQ) irimo 8-mikorobe itandukanye na antibiyotike ya fluoroquinolone kuko idafite fluor kumwanya wa 6 wa nucleus yababyeyi, ariko iracyafite imbaraga mubikorwa bya antibacterial vitro.nemonoxacin ni NFQ nshya itoranya bagiteri topoisomerase inhibitor.
Ugereranije na fluoroquinolone iri ku isoko, Nenofloxacin ihagarariye icyiciro gishya cy'imiti yubatswe.nemonocacin (TG-873870), imiti mishya ya quinolone yakozwe na Procter & Gamble (P&G), yerekanye ibikorwa bikomeye bya antibacterial kurwanya indwara zitandukanye zandurira mu mavuriro, harimo na Staphylococcus aureus na pnewumoniae yitwa Streptococcus.Ibyavuye mu bushakashatsi bwakozwe ku mbeba zanduye byerekanye ko ingaruka za antibacterial ziki gicuruzwa zari zikomeye kurusha quinolone nyinshi.Mubyongeyeho, ibicuruzwa bifite imiti myiza ya farumasi kandi byihanganirwa.