13590-42-6 H-Asp (OBzl) -NCA

Ubushakashatsi bwibinyabuzima:
Muri synthesis ya peptide, H-Asp (OBzl) -NCA ikora nkibice byingenzi byubaka muguhuza iminyururu ya peptide irimo aside aside ikurikirana.
Itsinda ryaryo rya benzyl ester rikora nkitsinda ririnda, ryemerera kwinjiza imiti yihariye mugihe cya synthesis ya peptide, ishobora gukurwaho mugihe gikwiye kugirango ubone aside irike yifuzwa.
Mu bushakashatsi bwo guhindura poroteyine cyangwa peptide, H-Asp (OBzl) -NCA irashobora gukoreshwa mugutangiza imiti yihariye ihindura iperereza kugirango harebwe uburyo ibyo bihindura bigira ingaruka kubikorwa byibinyabuzima cyangwa imikoranire nizindi molekile za poroteyine cyangwa peptide.
Kuvumbura ibiyobyabwenge:
H-Asp (OBzl) -NCA irashobora kuba intangarugero ya sintetike cyangwa hagati ya molekile zibiyobyabwenge, bigatuma hashyirwaho imiterere yihariye yimiti mugihe cyo gutegura imiti kugirango ibone abakandida ibiyobyabwenge nibikorwa byibinyabuzima.
Binyuze mu myitwarire hamwe nibindi bice byibiyobyabwenge cyangwa molekile ikora mubinyabuzima, irashobora koroshya guhuza imiti ishingiye kuri peptide cyangwa imiti ya heterocyclic hamwe ningaruka zihariye zo kuvura.
Mubikorwa byo kuvumbura ibiyobyabwenge, H-Asp (OBzl) -NCA irashobora kandi gukoreshwa mugupima ibicuruzwa byinshi no gupima ibikorwa byibinyabuzima kugirango isuzume ibikorwa byurwego rwa peptide cyangwa abakandida banywa ibiyobyabwenge.
Inganda zimiti:
Mu nganda zimiti, H-Asp (OBzl) -NCA ikora nkibikoresho fatizo cyangwa intera yo gukora imiti ikora peptide ikora.
Binyuze mu myifatire ya aside irike cyangwa ibice by'ibiyobyabwenge, birashobora koroshya guhuza imiti ya peptide hamwe nibikorwa byihariye byibinyabuzima, nka antibiotike, imisemburo, inzitizi ya enzyme, nibindi byinshi.
Itsinda rya benzyl ester rigaragara mumiterere yaryo ririnda aside karubike ya acide ya aspartic, igira uruhare mu gutuza no kongera imbaraga za peptide mugihe cya synthesis.