15260-10-3 Tert-butoxycarbonyl-L-threonine (benzyl) -OH

Ifu yera ya kirisiti;Kudashonga mumazi na peteroli ether, gushonga muri Ethyl acetate na methanol;mp ni 115-116 ℃;Kuzenguruka byihariye [α] 20D + 15.8 ° (0.5-2.0 mg / ml, methanol).
Ikoreshwa muri synthesis ya polypeptide, nka monomer irinda aside amine.
O-benzyl-l-threonine yahagaritswe mu gisubizo cya dioxyde hanyuma ihindurwamo acide na tert-butylcarbonyl azide kugirango ibone ibicuruzwa bitavanze, byakuwe na Ethyl acetate kuri pH ya 9-10 hanyuma bongera gushyirwaho.
Igice gikora cya thymic oietin Ⅱ ya thymus isohoka.Thymoietin II ni uruganda rumwe rwa polypeptide rwitaruye imisemburo ya thymus.Igizwe na aside amine 49, naho peptide yumunyururu wa peptide igizwe na acide 5 amine ifite imirimo yose yumubiri nka thymoietin II.Kubwibyo, iki gice cya pentapeptide cyitwa thymus pentapeptide.Umweru wera wumye wumye cyangwa ifu.
Imwe mu nshingano za thymus pentapeptide ni ugutera T selile itandukanye.Irashobora guhitamo guhitamo guhindura Thy-1- prothorax selile Thy-1 + T.T gutandukanya selile byahujwe no kwiyongera kurwego rwa cAMP urwego.Ikindi gikorwa cyibanze cya thymus pentapeptides ni uguhuza kwakirwa kwihariye kwamaraso akuze ya selile T akuze, kongera urwego rwa cAMP rwimitsi, bityo bigatera urukurikirane rwimyanya ndangagitsina, ari naryo shingiro ryimikorere yubudahangarwa bw'umubiri.Muburyo busanzwe bwumubiri, thymus pentapeptide yerekanye ingaruka zitera ubudahangarwa bw'umubiri, zishobora kongera cyane igipimo cya E rosette nigipimo cyo guhinduranya lymphocytes ya splenic, kongera ibyiciro bitandukanye byubudahangarwa bwambere cyangwa ubwa kabiri, kandi byongera umubare wubwoko bwa IgM na IgG cyangwa IgA ubwoko bwa antibody ikora selile.Thymus pentapeptide irashobora kandi kongera imikorere ya fagocytose ya macrophage, ikongerera enzyme na phagocytose imikorere ya polymorphonuclear neutrophile, kongera antibody ikwirakwizwa, no kongera imikorere yubudahangarwa bwamaraso atukura.Thymus pentapeptide irashobora gukora CD4 na CD8 ingirabuzimafatizo nziza, kugirango selile yihariye ya Tc ibashe kuramba, ariko kandi irashobora gukora Th selile kandi igatera imikorere ya selile.Ingaruka zo kurwanya no kuvura indwara ya thymus pentapeptide ifitanye isano no kuzamura ibikorwa bya TC selile.Umubare ukwiye wa thymus pentapeptide urashobora kongera cyane umusaruro wa interferon mukurinda indwara.Gutera no guteza imbere T selile itandukanye no gukura;CD4 / CD8 yakunze kuba ibisanzwe muguhuza igipimo cya T lymphocyte;Kongera imikorere ya fagocytose ya macrophage;Kongera imikorere yumubiri wamaraso utukura;Kongera ibikorwa bya selile naturel;Ongera urwego rwumusaruro wa interleukin-2 no kwerekana imvugo;Kongera umusaruro wa γ interferon mu maraso ya periferique mononuclear selile;Kongera ibikorwa bya SOD muri serumu.
Irashobora gukoreshwa mubarwayi bafite ibibyimba bibi bafite imikorere mibi yumubiri nyuma ya radiotherapi na chimiotherapie.Kuvura hepatite B;Ibikorwa bikomeye byo kubaga n'indwara zikomeye;Indwara za Autoimmune nka rubagimpande ya rubagimpande, lupus erythematosus;Ubwoko bwa diyabete yo mu bwoko bwa II, syndrome de menopause;Umuntu ufite intege nke z'umubiri.