1799443-50-7 Fmoc-N-Me-D-Tyr (tBu) -OH

Fmoc-N-Me-D-Tyr (TBu) -OH, izwi kandi nka N-α- (9-fluorenylmethoxycarbonyl) -N-α-methyl-D-tyrosine tert-butyl ester, ni inkomoko ya aside amine ikingira ikunze gukoreshwa muri synthesis ikomeye ya peptide.Uru ruganda ruhuza itsinda ririnda Fmoc kuri terminus ya amino na est-tert-butyl (TBu) ester irinda fenolike hydroxyl ya D-tyrosine.

Itsinda rya Fmoc, nkuko byavuzwe haruguru, rihamye kandi rishonga mumashanyarazi, bigatuma bikwiranye na peptide.Irashobora gukurwaho byoroshye mugihe cya alkaline, itanga uburyo bwo guteranya peptide ikurikiranye.Ku rundi ruhande, ester ya tert-butyl, irinda hydroxyl ya fenolike ya D-tyrosine, ikemeza ko itajegajega kandi ikagira isuku mu gihe cya synthesis.

Ikoreshwa ryibanze rya Fmoc-N-Me-D-Tyr (TBu) -OH ni mugutegura peptide irimo D-tyrosine.Bakoresheje iyi aside ikomoka kuri aside amine, abashakashatsi barashobora kumenyekanisha D-tyrosine hamwe na hydroxyl ya amino na fenolike ya hydroxyl irinzwe murwego rwa peptide.Ibi bitanga kugenzura neza imiterere ya peptide kandi byorohereza kwinjiza andi acide amine no guhindura imyanya yihariye murwego rwa peptide.

D-Tyrosine ni aside amine idasanzwe ishobora kwinjizwa muri peptide kugirango yige imiterere y’ibinyabuzima cyangwa gukora peptide igereranya nibikorwa byahinduwe.Peptide irimo D-tyrosine irashobora kugira ibikorwa bitandukanye byibinyabuzima ugereranije na L-tyrosine bagenzi babo, kubera itandukaniro rya stereochemiki iri hagati ya acide ebyiri za amino.