22254-24-6 8-Isopropylatropinium bromide

Ipratropium bromide izwi kandi nka Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, na ipratropium bromide.Nifu ya kirisiti yera ifite uburyohe bukaze.Gushonga ingingo 232 ℃ -233 ℃.Gushonga mumazi, gushonga gato muri Ethanol, kudashonga mubindi bimera.Izina ryimiti: Bromated α- (hydroxymethyl) -phenylacetic aside - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.Numuti wa anticholinergique, ufite ingaruka zikomeye zo kuruhuka kumitsi yoroshye ya bronchial hamwe ningaruka zo kurwanya indwara zidakira zifata ibihaha.Ingaruka zayo ziragaragara, ingaruka zihuse nigihe kirekire.Ipratropium bromide kandi igenzura ururenda rwa glande kandi igateza imbere ciliary, bityo bikagabanya inzitizi ziva mumyuka kugirango zihumeke neza.Hagati aho, kugabanuka kwa spum na byo bigabanya bronchospasm iterwa no kurakara kwa bronchial.Kurinda no kuvura asima ya bronchial na bronhite idakira, cyane cyane kubarwayi badashobora kwihanganira ikoreshwa rya β-agonist imitsi, tachycardia.Iki gicuruzwa kirashobora gukoreshwa hamwe na beta-agoniste kugirango bongere imbaraga za mugenzi wabo, nko gufatanya na finoterol gukora aerosol (BERODU - AL) kuri asima, bronhite idakira na emphysema.Ugereranije na β-adrenergic reseptor stimulator (urugero, isopropyl epinephrine), iki gicuruzwa gifite ingaruka nke z'umutima-damura, kandi ugereranije na β2-reseptor itera imbaraga (urugero, Suquanling), iki gicuruzwa gifite ingaruka zikomeye zo kugenzura ingano ya flegm.
Shiramo umwuka.40 ~ 80μg rimwe, inshuro 2 ~ 4 kumunsi.Mugihe ukoresheje, banza ukureho igifuniko cy'igikonoshwa, shyira igifuniko cy'igikonoshwa ijisho kuri nozzle, uhindure icupa hejuru, ushiremo igikonoshwa mu kanwa, ugamije umuhogo, unywe gaze icyarimwe, kanda nozzle kuri valve, uhumeka amazi, fata umwuka wawe akanya.Subiramo ifoto yavuzwe haruguru nibiba ngombwa.Aerosol: 0.025% igisubizo.Tablet: 10mg / ibinini.
Uburozi bukabije bwa anticholinergique burashobora kuvurwa hamwe na cholinesterase inhibitor.
Ingaruka mbi za ipratropium bromide isa na atropine, ishobora gutera palpitation, kubabara umutwe, kuzunguruka, guhagarika umutima, isesemi, kuruka, kubabara gastrointestinal, guhinda umushyitsi, kutabona neza, umunwa wumye, inkorora, dysuria, kwiyongera kwibimenyetso byubuhumekero no guhubuka.
Ipratropium bromide ni antagonist ya muscarinic, bronchodilator, n'umunyu wa isopropyl wa AtropineN.
Ipratropiumbromide na Formoterol byahujwe igice kugirango birinde ibihaha gutwika karande no kwagura ibihaha, kugabanya neutrophile muguhagarika ibikorwa binyuze muri MMP-9.Ipratropiumbromide (1nM) yongereye cyane calcium bromide ya calcium, igabanya gutatana imbere kandi yongera annexin-V guhuza.Nyuma yo kuvura Ipratropiumbromide, hemolysis yiyongereyeho gato ariko ku buryo bugaragara.Ipratropiumbromide itera kwiyahura kwamaraso yumutuku utukura cyangwa eryptose, cyane cyane biterwa na calcium.
Guhumeka ifu ya Ipratropium yumye (DPI) yari bronchodilator ikora neza muguhagarika amafarashi ku gipimo cya 2400 mg / ifarashi, ariko ntigire ingaruka nke kuri kalibiri yo hejuru yumuyaga mugihe cyo gukira.Imbeba zavuwe na kadmium, Ipratropium yongereye cyane ingirabuzimafatizo ya parenchymal inflammatory yinjira kandi yitegereza ibihaha byinshi bifitanye isano.Ipratropium irinda igice ibihaha gutwika kugabanya neutrophil kwinjira.Muri Gineya ingurube ya tracheal imitsi yoroshye, Ipratropium ni antagonist ibuza prebound muscarinic inhibitory reseptor ya nervice parasimpatique.Ipratropium nayo yerekanwe ko ari antagonist ikomeye nyuma yo guhuza imitsi ya muscarinic inhibitory reseptors.Ipratropium igabanya impinduka nini kumuvuduko wigituza kandi ikongerera imbaraga (Cdyn) muburyo bwo guhumeka neza (Pplmax yiyongera) hamwe no kurwanya ibihaha (RL) kumafarasi.