52558-24-4 (S) -3- (tert-Butyloxycarbonylamino) -2-aside aside hydroxypropionic

. hiyongereyeho ibitonyanga. Igisubizo cyakorewe mubushyuhe bwicyumba cyamasaha 9. Icyiciro cyamazi cyahinduwe kuri pH 2 hamwe na acide hydrochloric ya 4 mol / L, hanyuma ikuramo na dichloromethane / methanol (v / v = 5/1, 50 mL × 3 .
Kubisubizo bitangaje bya S-isoserine (4.0 g, 0,038 mol) muri dioxane: H2O (100 mL, 1: 1 v / v) kuri 0 ° C hiyongereyeho N-methylmorpholine (4,77 mL, 0.043 mol), ikurikirwa na BoC2O (11.28 mL, 0.049 mol) kandi reaction yabyutse ijoro ryose hamwe n'ubushyuhe buhoro buhoro ubushyuhe bwicyumba.Glycine (1.0 g, 0.013 mol) noneho yongewemo hanyuma reaction irabyutsa iminota 20.Igisubizo cyakonje kuri O0C hanyuma yicara aq.NaHCO3 (75 mL) yongeyeho.Igice cyamazi cyogejwe hamwe na Ethyl acetate (2 x 60 mL) hanyuma acide kuri pH 1 hamwe na NaHSO4.Uyu muti waje gukurwa hamwe na Ethyl acetate (3 x 70 mL) hanyuma ibyo bice kama kama byumye hejuru ya Na2SO4, birayungurura hanyuma byibanda kumisha kugirango bitange N-Boc-3-ammo-2 (S) -hidroxy- propanoic aside . , 2 H), 2.09 (s, 1 H), 1.42 (s, 9 H);13C NMR (IOO MHz, CDC13) δ 174.72, 158.17, 82, 71.85, 44.28, 28.45.
N-Boc-3-amino-2 (S) -hidroxy-protionic aside;Kubisubizo bitangaje bya S-isoserine (4.0 g, 0,038 mol) muri dioxane: H2O (100 mL, 1: 1 v / v) kuri 0 ° C hiyongereyeho N-methylmorpholine (4,77 mL, 0.043 mol), ikurikirwa na BoC2O (11.28 mL, 0.049 mol) kandi reaction yabyutse ijoro ryose hamwe n'ubushyuhe buhoro buhoro ubushyuhe bwicyumba.Glycine (1.0 g, 0.013 mol) noneho yongewemo hanyuma reaction irabyutsa iminota 20.Igisubizo cyakonje kugeza kuri 0 ° C hanyuma cyicara aq.NaHCO3 (75 mL) yongeyeho.Igice cyamazi cyogejwe hamwe na Ethyl acetate (2 x 60 mL) hanyuma acide kuri pH 1 hamwe na NaHSO4.Uyu muti waje gukurwamo na Ethyl acetate (3 x 70 mL) hanyuma ibyo bice kama kama byumye hejuru ya Na2SO4, birayungurura hanyuma byibanda kumisha kugirango bitange N-Boc-3-amino-2 (5) -hidroxy- propanoic aside . , 2 H), 2.09 (s, 1 H), 1.42 (s, 9 H);13C NMR (100 MHz, CDC13) δ 174.72, 158.17, 82, 71.85, 44.28, 28.45.