87512-31-0 Fluorene imikorerexy carbone-L-ALANYL-L-ALANINE

Iki gicuruzwa ni polypeptide igizwe na aside amine 28.Kuri N - acetyl - L - silk ammonia acyl - L - alpha amino ammonia acyl - L - propylene ammonia acyl - L - propylene ammonia acyl - L - valerian ammonia acyl - L - alpha amino ammonia acyl - L - Sue ammonia acyl - L - wire ammonia acyl - L - wire ammonia acyl - L - alpha glutamine - L - urumuri rutandukanye rwa ammonia acyl - L - Sue ammonia acyl - L - Sue ammonia acyl - L - lai ammonia acyl - L - alpha amino ammonia acyl - L - ammonia acile - L - lai ammonia acyl - L - alpha - glutamine - L - lai ammonia acyl - L - lai ammonia acyl - L - alpha glutamine - L - valerian ammonia acyl - L - valeriya ammonia acyl - L - alpha glutamine - L - alfa - glutamine - L - propylene ammonia vino - L - alfa - glutamine - L - asparagine.Ukurikije ibarwa rya anhydrous na acetike idafite aside, thymus irimo uburyo (C129 H215 N33O55) igomba kuba 95.0% ~ 105.0%.
Ibicuruzwa ni ifu yera cyangwa yera cyangwa misa irekuye.
Iki gicuruzwa gishonga muri acide trifluoroacetic, gushonga gake mumazi, ntigishobora gukomera muri acetonitrile, ether na trichloromethane.
Fata iki gicuruzwa, gipima neza, ongeramo 0,02mol / L ya fosiferi ya fosifate (pH 7.0) (fata 2.72g potassium dihydrogen fosifate, ongeramo 0.1mol / L sodium hydroxide 116.4ml kugirango ushonga, uyungurura amazi kuri 1000ml) hanyuma ukore a igisubizo kirimo 5mg muri buri 1ml.Kugenwa hakurikijwe amategeko (Umugereka ⅥE w'igice cya II cya Pharmacopoeia, integuro ya 2010), gutondeka byihariye bigomba kuba -100.0 ° kugeza -110.0 ° hashingiwe ku kubara ibintu bidafite aside irike na acide.
Uburyo bwibikorwa byiki gicuruzwa mu kuvura indwara ya hepatite B idakira no kongera imbaraga z'umubiri birinda gusobanurwa neza.Ubushakashatsi butari buke bwakozwe na vitro bwerekanye ko iki gicuruzwa gishobora guteza imbere imikurire ya Lymphocytes T itera mitogen ya lymphocytes yamaraso ya periferique, kongera urwego rwa interferon α, interferon γ, interleukin 2, interleukin 3 nibindi bintu byitwa lymphatique byasohowe na selile T. nyuma yo gukora antigen cyangwa mitogen, kandi mugihe kimwe byongera urwego rwimikorere ya lymphofactor hejuru ya selile T.Irashobora kandi kongera igisubizo cya allogeneic na autologique abantu bavanze lymphocytes binyuze mumikorere ya selile CD4.Iki gicuruzwa gishobora kongera igiteranyo cyimbere ya NK, kandi interferon irashobora kongera cytotoxicity.Mu bushakashatsi bwa vivo bwerekanye ko iki gicuruzwa gishobora kongera urwego rwimikorere ya reseptor ya interleukin-2 nu rwego rwo gusohora interleukin-2 muri lymphocytes yimbeba nyuma yo gukora cancanadin A.