Boc-We (Boc) -Aib-OH

Peptide Synthesis no Guhindura: Boc-His (Boc) -Aib-OH irashobora kuba nk'inyubako yubaka mumurongo wa peptide, igafasha kubaka peptide hamwe nurutonde rwihariye hamwe nimirimo ikoresheje guhuza nibindi bice bya aside amine cyangwa peptide.Iyi peptide yihariye-ikoreshwa muburyo bukoreshwa mubuvumbuzi bwibiyobyabwenge, ubushakashatsi bwibinyabuzima, nibindi bice bifitanye isano.
Urebye kuba histidine (Iye) na α-aminoisobutyric aside (Aib), imiterere yihariye ya acide amine itanga Boc-His (Boc) -Aib-OH ifite uruhare runini muburyo bumwe na bumwe bwa peptide.Birashobora kuzamura ituze nibikorwa byibinyabuzima bya peptide.
Ubushakashatsi bwibikorwa bya Biologiya Ubushakashatsi n’amabwiriza: Boc-His (Boc) -Aib-OH ifite ibikorwa byibinyabuzima byihariye, bituma iba igikoresho cyingirakamaro mubushakashatsi bwibikorwa byibinyabuzima.Abashakashatsi barashobora kuyinjiza muri sisitemu y’ibinyabuzima kugira ngo barebe ingaruka zayo mu ngirabuzimafatizo, bityo barusheho gusobanukirwa byimbitse ku buryo bwa physiologique na patologique.
Mugukoresha imidazole itsinda rya histidine hamwe nuburyo budasanzwe bwa acide α-aminoisobutyric, Boc-His (Boc) -Aib-OH irashobora guhindura imikoranire yayo na reseptors cyangwa izindi biomolecules, igenga ibisubizo byihariye byibinyabuzima cyangwa inzira yo gutambutsa ibimenyetso.
Gutegura ibiyobyabwenge niterambere: Boc-His (Boc) -Aib-OH ifite agaciro gakoreshwa mubijyanye no kuvumbura ibiyobyabwenge.Guhindura ibyubaka cyangwa gutezimbere birashobora kuganisha kumurongo hamwe nibikorwa byihariye bya farumasi, nkibiyobyabwenge byabakandida kugirango hakorwe iperereza niterambere.
Urebye ibyuma bishoboka ion chelating yibiranga itsinda rya imidazole ya histidine hamwe na biocompatibilité ya acide α-aminoisobutyric, Boc-His (Boc) -Aib-OH irashobora kuba igamije guteza imbere imiti igezweho yibasira indwara cyangwa intego yibinyabuzima.
Ubushakashatsi bwibinyabuzima na Biofiziki: Boc-His (Boc) -Aib-OH irashobora kuba urugero rwicyitegererezo cyo kwiga uburyo bwimikoranire hagati ya peptide na biomolecules nka proteyine na ADN, hamwe no gufunga peptide no gutuza muri sisitemu y’ibinyabuzima.

Binyuze mu iperereza ku mikoranire yabyo na biomolecules zitandukanye, hashobora kugerwaho gusobanukirwa neza imiterere ya biohimiki n'imikorere ya peptide.